A syndrome of complex dysostosis of the upper extremity and disturbances of heart rhythm.
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| Tabatznik's syndrome |
There is brachytelephalangy of the thumbs with shortening and hypoplasia of the fourth and fifth metacarpals in some cases. Addition disorders include sloping shoulders, hypoplastic deltoid muscles, short arms, flaring of the lower end of the humerus, flaring and obliquity of the lower end of the radius, and absent styloid process of the ulna. Inheritance is autosomal dominant or X-chromosomal dominant.
More details: 📖 The Wrist: Diagnosis and Operative Treatment
Bernard Tabatznik (1927 - 2016), American internist and cardiologist.
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| Bernard Tabatznik |
Bernard Tabatznik was medical director of the North Charles Hospital, Baltimore, Maryland, USA. He was born in Mir, in what was then Poland, but moved with his parents in his pre-teen years to South Africa. He was the son of Mendel Tabatznik, who wrote poetry in Yiddish and accumulated an extensive library of Yiddish literature; he later founded a painting contracting firm in burgeoning Johannesburg. Bernard Tabatznik attended high school in Johannesburg and then enrolled at the University of Witwatersrand Medical School in 1943. His close friends called him ‘Taba’. He loved to play with names; during his internship at Baragwanath Hospital in Johannesburg he elected to be called ‘Tshabalala’, a popular Zulu clan name.
In 1951 he travelled to the UK in pursuit of further training at the National Heart Hospital, the National Hospital for Nervous Diseases and the Postgraduate Medical School of London. He also worked in Hillingdon and Ashford. He returned to South Africa for a couple of years as a physician in the professorial unit at the Non-European Hospital and also at Johannesburg General Hospital.
Disillusioned by the tightening of legislated racial discrimination in South Africa, he departed for the United States in 1959 to pursue a fellowship in cardiology at Johns Hopkins University School of Medicine in Baltimore, Maryland. Shortly afterwards, he was appointed as physician-in-chief at Sinai Hospital, originally the Hebrew Hospital and Asylum of Baltimore, established in 1866. He became director of its growing division of cardiology and cardiopulmonary laboratory, appointments he held until 1972, when he was appointed medical director at North Charles Hospital, also in Baltimore.
For the next several years he was the principal investigator in a series of drug trials in the management of angina pectoris. He was the main author of more than 60 publications, covering a large range of subjects, including heart sounds, murmurs, postpericardiotomy syndrome and prolonged electrocardiographic monitoring.
He is probably best remembered for his role in the development of the implantable cardioverter defibrillator (ICD), a significant cardiovascular innovation of the 20th century, first developed at Sinai Hospital, Baltimore. As director of the cardiology division, Bernard Tabatznik was intimately involved in the initial stages of its development, having garnered together the team that eventually led to the first successful implantation in a human patient.
He had met up with Harold (Hans) Bix, who fled Austria in 1939, having learned the basics of cardiac arrhythmia from his mentor the legendary Karel Frederik Wenckebach [Munk’s Roll, Vol.V, p.440]. A group of physicians met each week to analyse recordings of cardiac arrhythmias. Continuous (Holter) monitoring of the electrocardiogram in ambulatory patients became available in 1961. Mieczyslaw Smaw (Michel) Mirowski, who had expatriated himself from Poland and moved via Kiev in the Ukraine, ultimately joined Sinai in Baltimore, working with a biomedical instrumentation engineer, William (Bill) Staewen, who with Mirowski designed and constructed a prototype defibrillator, which was tested in the dog laboratory, later followed by the development by an electronics company of a miniaturised version. The first implant in a human was performed at Johns Hopkins Hospital in 1980. In further development, the US Food and Drug Administration approved the use of the defibrillator in 1985, now used in prevention of malignant cardiac arrhythmias in a variety of disorders. In 1991 the biomedical engineers of Sinai Hospital were inducted into the Space Technology Hall of Fame, followed by induction into the National Inventors Hall of Fame in 2002.
References
• The Mammary Souffle of Pregnancey and Lactation.
Circulation, Dallas, Texas, 1960, 22: 1069–1073
Bernard Tabatznik and James P. Isaacs:
• Postpericardiotomy Syndrome Following Traumatic Hemopericardium.
The American Journal of Cardiology, New York, January 1961 7(1): 83-96.
Philip Rodin and Bernard Tabatznik:
• The effect of posture on added heart sounds.
British Heart Journal, London, 1963, 25 (1): 69-80.
Morton M. Mower, Bernard Tabatznik, William S. Staewen, Barry M. Cohen:
• A Practical Method Of Long Term Ecg Analysis.
The American Journal of Cardiology, New York, 1967, 19(1): 143-144
Mottis N. Kotler, B ernard Tabatznik, Morton M. Mower
and Suketami Tominaga:
• Prognostic Significance of Ventricular Ectopic Beats with Respect
to Sudden Death in the Late Postinfarction Period.
Circulation, Dallas, Texas, 1973, 47: 959-966
C. D. Furberg, T. A. Manolio, B. M. Psaty, D. E. Bild, N. O. Borhani,
A. Newman, B. Tabatznik, P. M. Rautaharju:
• Major electrocardiographic abnormalities in persons aged 65 years
and older (the Cardiovascular Health Study). The Cardiovascular Health
Study Collaborative Research Group.
The American journal of cardiology, New York, 1992, 69(16): 1329-1335.
J. M. Gardin, N. D. Wong, W. Bommer, H. S. Klopfenstein, V. E. Smith,
B. Tabatznik, D. Siscovick; S. Lobodzinski; H. Anton-Culver; T. A. Manolio:
• Echocardiographic design of a multicenter investigation of
free-living elderly subjects: The Cardiovascular Health Study.
Journal of the American Society of Echocardiography, St.Louis, 1992, 5(1): 63-72
T. A. Manolio; C. D. Furberg; P. M. Rautaharju; D. Siscovick; A. B. Newman;
N. O. Borhani; J. M. Gardin; B. Tabatznik:
• Cardiac arrhythmias on 24-h ambulatory electrocardiography in older women
and men: The Cardiovascular Health Study.
Journal of the American College of Cardiology, New York, 1994, 23(4): 916-925.
M. Mirowski and Bernard Tabatznik:
• The Spatial Characteristics of Atrial Activation in Ventriculo-Atrial Excitation.
Chest, Chicago, 1970, 57(1): 9-17.
A. Collado, M. M. Mower, B. Tabatznik:
• Left atrial parasystole. Chest, Chicago, 1971, 59(2): 214-216.
Elliott Antman, James Muller, Sheldon Goldberg, Rex MacAlpin, Melvyn Rubenfire,
Bernard Tabatznik, Chang-seng Liang, Fred Heupler, Stephen Achuff, Nathaniel Reicher,
Edward Geltman, Nicholas Z. Kerin, Raymond K. Neff, Eugene Braunwald:
• Nifedipine Therapy For Coronary-Artery Spasm.
The New England Journal of Medicine, Boston, 1980, 302(23): 1269-1273.
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